Can you take ibuprofen with isoniazid

They will have vital signs taken and give a blood sample. Women will have a pregnancy test. Participants cannot take any other medicines during the study, including vitamins. Participants will be assigned to one of three groups. Each group will take a different study drug, once or twice a day, for 19 23 days. At the baseline study visit, they will get a supply of the study drug tablets and instructions for taking them. Participants will keep a medicine diary to serve as a memory aid for taking medicine and reporting any side effects that they may experience.

Participants will have 8 or 9 study visits over about 40 days. The number of visits depends on which group the person is assigned to. Participants will fast before study visits. The baseline visit will last about 2 3 hours.

There will be long visits that will last for about 12 hours. The other visits will last about 1 hour. During all study visits, screening procedures will be repeated. During long visits, an intravenous IV line will be inserted into an arm vein with a needle.

It will be used to take blood. Although this regimen offers several potential benefits, the use of weekly RPT plus INH is not currently recommended in adults infected with human immunodeficiency virus HIV on antiretroviral therapy ART due to limited evidence on drug interactions with antiretrovirals ARVs.

Cobicistat levels will only be assessed if DRV concentrations are significantly decreased. The following PK parameters will be compared between phases: area under the curve over the dosing interval, maximum plasma concentration, time to maximum plasma concentration, terminal half-life, apparent oral clearance, and minimum plasma concentration.

Adverse events will be graded and recorded. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. For female subjects able to become pregnant i. Acceptable methods are as follows:.

A subject will be ineligible for this study if 1, or more, of the following criteria are met:. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms. Save this study. Warning You have reached the maximum number of saved studies Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government.

Read our disclaimer for details. Last Update Posted : October 15, Study Description. Objective: To learn how anti-HIV and anti-TB drugs affect each other so that people taking these drugs together can be treated safely.

Avoid taking an antacid within 1 hour after you take Rifater. Some antacids can make it harder for your body to absorb this medicine. Avoid foods that are high in tyramine or histamine, listed below. Tyramine or histamine can interact with this medication and cause unpleasant side effects.

These foods include:. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, and joint pain or stiffness. Rifater can cause severe liver symptoms, especially in people who are 35 and older.

Call your doctor at once if you have any of these early signs of liver damage: nausea, vomiting, upper stomach pain, weakness, tiredness, loss of appetite, or yellowing of your skin or eyes. This is not a complete list of side effects and others may occur.

Call your doctor for medical advice about side effects. Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Rifater can harm your liver, especially if you also use certain medicines for infections, tuberculosis, depression, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis including Tylenol, Advil, Motrin, or Aleve.

Many drugs can affect isoniazid, pyrazinamide, and rifampin, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Skip to main content. Health Information Library. What is the most important information I should know about this medicine? What is isoniazid, pyrazinamide, and rifampin? Rifater may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking this medicine?

How should I take this medicine? What happens if I miss a dose? What happens if I overdose? What should I avoid while taking this medicine? Avoid drinking alcohol. It may increase your risk of liver damage. What are the possible side effects of this medicine? What other drugs will affect this medicine?

Where can I get more information? Your pharmacist can provide more information about isoniazid, pyrazinamide, and rifampin. Copyright Cerner Multum, Inc. Version: 9. Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.